Housebound and suffering from mental collapse, Charlotte (Jennifer Bates) receives an encouraging message from an unlikely herald (Mary Kraft). Dr. Hayes (John Schmedes) requests Charlotte’s special assistance in a personal investigation into the circumstances of Karen’s crime.
Somerhill (Daniel May) receives word of Hayes’s (John Schmedes) revelation from both the proud doctor and a rogue agent (Andrew Benator), who is furious at having been exposed. Unsatisfied with Hayes’s explanation, Verdrey (Lisa Paulsen) begins to investigate the identity and purpose of the Society for the Investigation of Human Ecology.
Intent on exposing Karen’s (Hannah Fierman) secrets, Dr. Hayes (John Schmedes) subjects her to chemical hypnosis and coerces her to reenact the ill-fated events that occurred in room 512 of the Dixie Hotel. His unhealthy obsession with Karen reaches new depths, but his unorthodox form of role-playing leads to an unexpected breakthrough.
Karen (Hannah Fierman) spends days confined to a “sleep room,” where a mind-numbing combination of treatments are administered. Pleased with Hayes’s progress, Somerhill (Daniel May) encourages the doctor (John Schmedes) to become more aggressive in his therapies, just as the Ward Head Nurse, Verdrey (Lisa Paulsen), begins to question Hayes’s methods. Charlotte (Jennifer Bates) is released.
Dr. Hayes (John Schmedes) conscripts Karen (Hannah Fierman) to tape record a message of cooperation and compliance, to be used in future therapies. When Karen (Hannah Fierman) attempts to escape, one of the attendants (Joe Sykes), who is prone to bullying and abuse, volunteers to find her. And succeeds.
Dr. Hayes (John Schmedes) realizes he must cultivate more ambitious therapies if he expects to win the fiscal support of a large research group, represented by Somerhill (Daniel May). He decides to prove himself by forcing Karen (Hannah Fierman) to reveal the truth about the crime at the Dixie Hotel. Charlotte (Jennifer Bates), one of the better-adapted patients on the ward, grows jealous of the doctor’s obvious fascination with the new patient.
After being apprehended fleeing the scene of a crime, an outspoken woman, Karen (Hannah Fierman), is placed in the Central State Hospital at New Canaan, for examination and evaluation. After a terse interview with Dr. Hayes (John Schmedes), she is quickly acquainted with the harsh realities of life in B Ward.